Lesson 1, Topic 1
In Progress

Physiology of the Gastrointestinal System

April 11, 2024

Learning Objective: Differentiate among digestion, absorption, and excretion.
      The role of the digestive system is to provide nutrients to the cells of the body. Four processes occur in the digestive system:
                • Ingestion: The intake of food and liquids into the body
                • Digestion: The breakdown of food into chemical substances
                • Absorption: The passage of substances and liquids through the lining of the GI tract into the body fluids and tissues
                • Excretion: The elimination of indigestible materials and waste products of metabolism
The following sections focus on the digestion, absorption, and elimination processes in the body.

19.5 Critical Thinking Application
Summarize the four processes that occur in the GI system.

Digestion
Learning Objective: Describe the process of mechanical digestion and chemical digestion.
      Once food is ingested, it must be digested for absorption to occur. Two digestive processes happen to break down food into chemical substances:
                • Mechanical digestion: The breakdown of food into smaller particles. This process starts in the mouth as the food is being chewed. The smooth muscles in the stomach provide the churning and mixing action, which also aids in the breakdown of the food.
                • Chemical digestion: The smaller particles of food are broken down into small molecules that can be absorbed.

Chemical Digestion
Chemical digestion starts in the mouth. During mastication (the process of chewing), saliva moistens and aids in the breakdown and swallowing (deglutition) of food. Saliva contains an enzyme called salivary amylase, which starts to break down complex carbohydrates.
      In the stomach, hydrochloric acid softens and breaks down proteins and other foods. The pH of hydrochloric acid also kills many pathogens (e.g., bacteria) that are consumed. Pepsin, an enzyme found in the gastric juices, breaks down proteins into amino acids.
      Hydrochloric acid, amino acids, or fatty acids in the stomach or duodenum stimulate the small intestine to secrete cholecystokinin (CCK), a hormone. CCK causes the gallbladder to contract and release bile into the duodenum through the common bile duct. Bile from the liver is also secreted in the duodenum and emulsifies fats. CCK also increases secretion of pancreatic juices, which contain the following enzymes:
                • Trypsin and chymotrypsin: Break down proteins into amino acids
                • Amylase: Breaks down carbohydrates into sugars
                • Lipase: Breaks down fats into fatty acids and glycerol
      Pancreatic juices also contain sodium bicarbonate, which helps to neutralize the acidity of the chyme in the duodenum.
      In the small intestine, brush-border enzymes (sucrase, lactase, and maltase) are found in the microvilli. These enzymes help with the final breakdown of carbohydrates:
                • Sucrase: Breaks down sucrose (or cane sugar) into glucose and fructose.
                • Lactase: Breaks down lactose (found in milk) into galactose and glucose.
                • Maltase: Breaks down maltose (from starches) into glucose.

19.6 Critical Thinking Application
Summarize the chemical digestion of carbohydrates, proteins, and fats.

Absorption and Excretion
Learning Objective: Discuss the processes of absorption and excretion.
      Once chemical digestion is complete, small nutrient molecules move from the small intestines into the bloodstream through the process of absorption. As mentioned earlier, the villi and microvilli in the small intestine increase the surface area, which makes the absorption of nutrients more efficient. The lacteal in the villus absorbs lipids, and the capillary absorbs glucose and amino acids. Chemical digestion and nutrient absorption are completed by the time chyme leaves the small intestine.
      As chyme moves through the large intestine, water and electrolytes are reabsorbed to prevent dehydration. The consistency of chyme changes to a soft-formed solid, called feces, which is excreted. The composition of feces is water, bacteria, undigested carbohydrates, fiber, and some protein and fat.

Life Span Changes of the Gastrointestinal System
Learning Objective: Discuss the processes of absorption and excretion.
      Throughout life, changes occur in both the GI tract and the accessory organs. The following sections discuss the changes that occur with age and pregnancy.


Changes with the GI Tract
Learning Objective: Discuss the changes in the GI tract.
      At birth, the baby’s digestive system is not fully mature. The infant does not have teeth to help break down food. Salivary secretions (which start starch breakdown) are insufficient until about 6 months of age. Pancreatic amylase levels may not be sufficient until 12 to 18 months of age. Bile salts and lipase levels are not sufficient until 6 to 9 months of age.
      During pregnancy, progesterone (a hormone) causes the smooth muscles to relax. This causes less peristalsis in the digestive system, thus slowing digestion. Gallbladder emptying may be delayed, leading to gallstone formation. Morning sickness, constipation, and heartburn can result from digestive system changes.
      With age, the stomach cannot accommodate as much food because of decreased elasticity. The stomach empties more slowly. The lactase levels also decrease with age, leading to lactose intolerance (milk products). Bacterial overgrowth (excessive growth of certain intestinal bacteria) is more common with age and leads to bloating, weight loss, and pain. Bacterial overgrowth can also lead to reduced absorption of certain nutrients (e.g., iron, calcium, and vitamin B12). With aging, constipation is more common and can be caused by many factors, including the following:
            • Slowing of fecal contents through the large intestine, allowing for more water absorption
            • Increased use of drugs that can cause constipation
            • Decreased physical activity and fluid intake


Changes with the Accessory Organs
Learning Objective: Describe the age-related changes that occur with the accessory organs.
      Age-related changes can be seen with the accessory organs. A decrease of salivary flow is not related to age, although it is common in older adults. It is related to diseases, medications, and head and neck radiation therapy (used for cancers). The pancreas decreases in weight as some tissue is replaced with scar tissue, although these changes do not affect the organ’s ability to produce digestive enzymes and sodium bicarbonate. With age, the liver gets smaller, and blood flow decreases. Liver function test results, however, are unchanged. Metabolism of many substances decreases, which affects drug metabolism; thus, older adults may experience dose-related side effects. The production and flow of bile decrease with age, leading to more gallstones.


Common Signs and Symptoms of Gastrointestinal Disorders
            • Constipation, diarrhea, hematochezia (bloody stool), and melena (black, tarry stools)
Pyrosis (heartburn), dyspepsia (indigestion), and flatus (gas)
Halitosis (bad-smelling breath)
Nausea, vomiting, and hematemesis (vomiting of blood)
Jaundice (yellowing of the skin and whites of the eyes caused by elevated bilirubin levels)